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LCU Think Tank 1 | 2008 Audio
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LCU Think Tank 1 | 2008
Go to Flex and EGFR
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Flex and EGFR
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Track 1
FLEX study: Cetuximab and chemotherapy for non-small cell lung cancer (NSCLC)
Track 2
Current and future roles of EGFR testing and mutation analyses in NSCLC
Case Discussion 1
(from the practice of Dr Lynch)
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Track 1
Case discussion: A 68-year-old man who is a smoker with a history of CAD and current antiplatelet treatment with a moderately differentiated adenocarcinoma that is EGFR-positive, EGFR wild-type, RAS wild-type, TTF-1-positive, CK7-positive and CK20-positive Stage IV NSCLC
Track 2
Anticoagulation therapy and the use of bevacizumab
Track 3
First-line therapy options for bevacizumab-eligible patients with metastatic NSCLC
Track 4
Considerations for the use of a first-line cetuximab-based regimen in NSCLC
Track 5
Tolerability of cetuximab-associated skin rash
Track 6
Effect of Asian ethnicity on prognosis and response to cetuximab in FLEX
Track 7
Safety of chemotherapy/bevacizumab for patients with nonsquamous cell NSCLC and treated brain metastases: Data from ATLAS and PASSPORT
Track 8
Identification of patients with NSCLC for whom bevacizumab offers a favorable benefit-risk ratio
Case Discussion 2
(from the practice of Dr Lilenbaum)
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Track 1
Case discussion: A 69-year-old prior smoker with well-controlled hypertension and Stage IVA NSCLC
Track 2
Treatment after disease progression on first-line carboplatin/paclitaxel and bevacizumab
Track 3
Continuation of bevacizumab upon disease progression
Track 4
Patient preference for and tolerability of continued bevacizumab treatment
Track 5
Clinical implications of the study of maintenance pemetrexed in Stage IIIB/IV NSCLC with no progression after four cycles of platinum-based induction chemotherapy
Track 6
Potential role of nanoparticle albumin-bound (
nab
) paclitaxel in NSCLC
Case Discussion 3
(from the practice of Dr Bunn)
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Track 1
Case discussion: A 55-year-old Chinese-American man who is a physician and a never smoker with de novo Stage IV, TTF-1-positive, EGFR gene-amplified, EGFR mutation-negative, K-ras mutationpositive NSCLC
Track 2
Available technologies for the assessment of EGFR mutation
Track 3
Clinical response and tolerability of first-line carboplatin/pemetrexed with bevacizumab/cetuximab
Track 4
SWOG-S0536: A Phase II trial of carboplatin, paclitaxel, cetuximab and bevacizumab followed by cetuximab/bevacizumab in advanced NSCLC
Track 5
Metastectomy with curative intent for an isolated splenic metastasis
Track 6
Radiation therapy and cetuximab followed by lobectomy and maintenance cetuximab
cetuximab/ bevacizumab
Track 7
Perspective on locoregional therapy for patients with oligometastatic NSCLC
Case Discussion 4
(from the practice of Dr Miller))
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Track 1
Case discussion: A woman who is a nonsmoker diagnosed with Stage IIIB, EGFR mutation-positive
NSCLC with bronchoalveolar features
Track 2
Magnitude and duration of response to EGFR tyrosine kinase inhibitors (TKIs) in patients with EGFR
mutations
Case Discussion 5
(from the practice of Dr Socinski))
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Track 1
Case discussion: A 65-year-old smoker with Stage IVA NSCLC
Track 2
Use of sunitinib in previously treated, advanced NSCLC
Track 3
Sunitinib-associated hypothyroidism
Track 4
Median number of treatment regimens administered for advanced NSCLC
Track 5
Referral of patients with lung cancer to medical oncologists
Track 6
Synergistic activity of radiation therapy and cetuximab
Track 7
Proposed addition of cetuximab to RTOG-0617: Standard versus high-dose radiation therapy with carboplatin/paclitaxel in Stage IIIA/IIIB NSCLC
Track 8
SWOG-S0533: A pilot trial of cisplatin/etoposide/radiation therapy followed by consolidation docetaxel/bevacizumab for inoperable, locally advanced Stage III NSCLC
Track 9
Potential role of maintenance therapy with targeted agents after chemoradiation therapy for Stage III NSCLC
Track 10
START: A Phase III study of the cancer vaccine Stimuvax
®
in unresectable Stage III NSCLC
Track 11
Role of pulmonary V20 values in planning chemoradiation treatment
Case Discussion 6
(from the practice of Dr Curran)
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Track 1
Case discussion: A 54-year-old woman with T2N3M0 NSCLC
Track 2
Caveats and considerations for the incorporation of cetuximab with chemoradiation therapy for
Stage III NSCLC
Track 3
Obligation for expert opinion to provide available safety and efficacy information when discussing nonstandard treatments
Case Discussion 7
(from the practice of Dr Natale)
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Track 1
Case discussion: A 57-year-old woman who is an oligosmoker who underwent a lobectomy and mediastinal lymph node dissection for T2N1M0 ERCC1-positive NSCLC
Track 2
Cisplatin/docetaxel as adjuvant chemotherapy for NSCLC
Track 3
Influence of ERCC1 and patient preference on the choice of adjuvant chemotherapy
Track 4
Use of cisplatin/pemetrexed for disease upstaged to Stage IIIA non-small cell lung adenocarcinoma on the basis of microscopic disease in the lymph nodes
Track 5
Key clinical trials of the dual TKI vandetanib in NSCLC
Track 6
Dual targeting of VEGF and EGFR with vandetanib
Track 7
Circulating VEGF as a potential predictive biomarker of vandetanib in patients with advanced NSCLC
Track 8
Anticipated safety of bevacizumab in the adjuvant setting
Track 9
Adjuvant chemotherapy for Stage IB NSCLC tumors smaller than four centimeters
Track 10
Role of patient preference in adjuvant treatment decision-making for Stage IB NSCLC
Case Discussion 8
(from the practice of Dr Wozniak)
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Track 1
Case discussion: A 79-year-old woman who never smoked and presented with T2N0M0 NSCLC and
underwent a right lobectomy with mediastinal lymph node sampling
Track 2
Benefits of adjuvant chemotherapy for the elderly with NSCLC
Track 3
Eligibility of patients with Stage IB NSCLC for RADIANT: Erlotinib with or without adjuvant chemotherapy